A Five year Audit of Different Paediatric Bony Lesions presented to a Tertiary Care Hospital.
Keywords:Benign, Ewing sarcoma,Malignant,Osteosarcoma,Paediatric.
Objective: To determine the pattern of paediatric bony tumours or tumour like lesions presenting to the Department of Orthopaedics & Spine Surgery Ghurki Trust Teaching Hospital Lahore in the past five years.
Methods:This retrospective Cohort study was conducted in Department of Orthopaedics & Spine Surgery Ghurki Trust Teaching Hospital Lahore.The records of all children with bony lesions fulfilling the inclusion criteria who presented to our hospital in time period extended from 1st April 2015 to 1st April 2021 were reviewed.The type of lesion, gender, site, histological type and treatment of each bony lesion was documented.
Results: The total number of children with tumour or tumour like bony lesions were 212.The mean age was 11.55±3.12 years. Male children were 145(68.39%) and female were 67(31.60%). The most common tumor site was distal femur noted in 65 (30.66%) children. Osteosarcoma was the predominant bone tumour diagnosed in 118(55.6%) children followed by with Ewing sarcoma in 32(15.1%), chondrosarcoma in 20(9.43%) and osteoid osteoma in 12(5.6%) chilfren. Excisional biopsy was the most common(38.20%,n=81) surgical intervention followed by incisional biopsy in 52(24.52%) children.
Conclusion: Tumour or tumour like bony lesions were more frequently detected in male children than in female children.Distal femur was the most commonly involved bone.Osteosarcoma was the most commonly diagnosed primary malignant bone tumour while Osteochondroma and Aneurysmal Bone Cysts were the most frequently detected benign bony lesions.
Gereige R, Kumar M. Bone lesions: benign and malignant. Pediatr Rev. 2010;31(9):355-362.
Vartevan A, May C, Barnes CE. Pediatric bone imaging: Differentiating benign lesions from malignant. Applied Radiology. 2018;47(7):8-15.
Wyers MR. Evaluation of pediatric bone lesions. Pediatr Radiol. 2010;40(4):468-473.
Khanna G, Bennett DL. Pediatric bone lesions: beyond the plain radiographic evaluation. Semin Roentgenol. 2012;47(1):90-99.
Sun Y, Liu X, Pan S, Deng C, Li X, Guo Q. Analysis of imaging characteristics of primary malignant bone tumors in children. Oncol Lett. 2017;14(5):5801-5810.
Collins M, Wilhelm M, Conyers R, Herschtal A, Whelan J, Bielack S,et al.Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis. J Clin Oncol. 2013;31(18):2303-2312.
Kaste SC: Imaging pediatric bone sarcomas. Radiol Clin North Am. 2011;49(4):749–65,
Costelloe CM, Madewell JE. Radiography in the initial diagnosis of primary bone tumors. AJR Am J Roentgenol. 2013;200(1):3-7.
Rana KA, Meyer J, Ibrahim S, Ralls M, Kent PM. The role of imaging of malignant bone tumors in children and young adults. Curr Probl Cancer. 2013 ;37(4):181-91.
Eftekhari F. Imaging assessment of osteosarcoma in childhood and adolescence: diagnosis, staging, and evaluating response to chemotherapy. Cancer Treat Res. 2009;152:33-62.
Petca RC, Gavriliu S, Burnei G. Retrospective clinicopathological study of malignant bone tumors in children and adolescents in Romania - single center experience. J Med Life. 2016;9(2):205-210.
Gawande VB., Aniruddha C. A Retrospective Analysis of Bone Tumours at Tertiary Care Hospital of Rural India: A 5 Years Analysis. Journal of Orthopedic Education. 2018;5(2).74-80.
Bamanikar SA, Pagaro PM, Kaur P, Chandanwale SS, Bamanikar A, Buch AC. Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital. JKIMSU. 2015;4(2):46-55.
Kaatsch P, Strothotte J, Becker C, Bielack S, Dirksen U, Blettner M. Pediatric bone tumors in Germany from 1987 to 2011: incidence rates, time trends and survival. Acta Oncol.2016 ;55(9-10):1145-1151.
Stiller CA, Bielack SS, Jundt G, Steliarova-Foucher E. Bone tumours in European children and adolescents, 1978-1997. Report from the Automated Childhood Cancer Information System project. Eur J Cancer.2006 Sep;42(13):2124-2135.
Gereige R, Kumar M. Bone lesions: benign and malignant. Peds in Review. 2010;31(9):355-363.
Ozkan EA, Goret CC, Ozdemir ZT, Yan?k S, Dogan M, Gonulta? A, et al, Pattern of primary tumors and tumor-like lesions of bone in children: retrospective survey of biopsy results. Int J Clin Exp Pathol. 2015 ;8(9):11543-11548.
Rutkowski M, Niewinska K. The Epidemiology of Benign Proliferative Processes of the Skeletal System in Children. Int J Environ Res Public Health. 2021;18(17):9338. doi: 10.3390/ijerph18179338.
Mohammed A, Sani MA, Hezekiah IA, Enoch AA. Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria. Afr J Paediatr Surg. 2010;7(1):16-18.
van den Berg H, Kroon HM, Slaar A, Hogendoorn P.Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA".J Pediatr Orthop.2008; 28(1):29-35.