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Surface Matters: Nanotechnology in Orthopaedics and Spine
Keywords:
Implant surface geometry, Total Knee Replacement, nanomaterial,, HydroxyapatiteAbstract
Implant surface geometry is important for biological response from surrounding tissue smooth surface to rough to nano-surface have variable response – from cellular and protein adsorption and bony integration, as one changes surface from macro to micro to nano. For stability at bone implant or bone on bone (fracture or graft healing). The surface is important consideration which is modified through osteo-immune cells – macrophages M1&M2 which help in bio-debridement then restore the bone biology and continuity.
Nanotechnology in orthopedics is hot and emerging topic for research and development. Implants as Total Hip Replacement /Total Knee Replacement etc. are now increasingly by coated with nanomaterial as Titanium (Ti) and Hydroxyapatite (HA) which result in better bondage, integration with host bone thus increasing stability and longevity of implant, thus reducing long term complications of loosening etc.
References
W. R. Smith, P. W. Hudson, B. A. Ponce, and S. R. Rajaram Manoharan,“Nanotechnology in orthopedics: A clinically oriented review,” BMC Musculoskelet. Disord., vol. 19, no. 1, pp. 1–10, 2018, doi: 10.1186/s12891-018-1990-1
R. Garimella and A. E. M. Eltorai, “Nanotechnology in orthopedics,” J. Orthop., vol. 14, no. 1, pp. 30–33, 2017, doi: 10.1016/j.jor.2016.10.026.
R. Olivares-Navarrete et al., “Rough titanium alloys regulate osteoblast production of angiogenic factors,” Spine J., vol. 13, no. 11, pp. 1563–1570, 2013, doi:10.1016/j.spinee.2013.03.047
Kalindu Perera, Ryan Ivone, Evelina Natekin, Cheryl. A. Wilga, Jie Shen and Jyothi U. Menon “3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci” Biotechnol”., 22 October 2021 | https://doi.org/10.3389/fbioe.2021.754113
Raju Vaishya,a Vipul Vijay,a,? Abhishek Vaish,b and Amit K. Agarwala “Computed tomography based 3D printed patient specific blocks for total knee replacement” (Journal of Clinical Orthopaedics and Trauma, 2018; 9: 254e259) https://10.1016/j.jcot.2018.07.013
